Intra‐tumoral Salmonella typhimurium induces a systemic anti‐tumor immune response that is directed by low‐dose radiation to treat distal disease
Intra‐tumoral Salmonella typhimurium induces a systemic anti‐tumor immune response that is directed by low‐dose radiation to treat distal disease
F. Avogadri,D. Mittal,5 Authors,M. Rescigno
2008 · DOI: 10.1002/eji.200738035
European Journal of Immunology · 43 Citations
TLDR
It is demonstrated that Salmonella‐based therapy coupled to low‐dose radiotherapy dampens tumor immune escape mechanisms at different levels and allows controlling systemic disease in a CD8+ T cell‐dependent manner.