Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
D. Cua,J. Sherlock,13 Authors,J. Sedgwick
2003 · DOI: 10.1038/nature01355
Nature · 3,104 Citations
TLDR
It is shown that the perceived central role for IL-12 in autoimmune inflammation, specifically in the brain, has been misinterpreted and that IL-23, and not IL- 12, is the critical factor in this response.