Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.
A. Andoh,Zhuobin Zhang,9 Authors,Y. Fujiyama
2005 · DOI: 10.1053/J.GASTRO.2005.06.071
Gastroenterology · 497 Citations
TLDR
IL-22 derived from activated T cells acts on SEMFs to elicit expression of proinflammatory cytokines and matrix-degrading molecules indicating proinflammatory/remodeling roles in IBD.