Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.
Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.
R. M. Simmons,D. Erikson,4 Authors,T. Spencer
2009 · DOI: 10.1210/en.2009-0060
Endocrinology · 69 Citations
TLDR
Investigation of temporal and spatial alterations in IGF binding protein (IGFBP)-1 and IGFBP3 in the ovine and bovine uterus reveals that IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus lengthening by stimulating migration and attachment of the trophectoderm.