Inhibition of GABA‐gated chloride channels by 12,14‐dichlorodehydroabietic acid in mammalian brain
Inhibition of GABA‐gated chloride channels by 12,14‐dichlorodehydroabietic acid in mammalian brain
R. Nicholson,G. Lees,Jian Zheng,B. Verdon
1999 · DOI: 10.1038/sj.bjp.0702419
British Journal of Pharmacology · 6 Citations
TLDR
12,14‐Cl2DHA inhibited all synaptic traffic and action currents in current clamped cells indicating that, in contrast to picrotoxinin (which causes paroxysmal bursting), it is not fully selective for the GABAA receptor‐chloride channel complex.