Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
M. Chircop,S. Perera,11 Authors,P. Robinson
2011 · DOI: 10.1158/1535-7163.MCT-11-0067
Molecular Cancer Therapeutics · 50 Citations
TLDR
The dynoles are a second class of dynamin GTPase inhibitors, with dynole 34-2 as the lead compound, that are novel antimitotic compounds acting specifically at the abscission stage, and cell death was induced specifically following cytokinesis failure.