Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals1
Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals1
S. Kreiter,Abderraouf Selmi,6 Authors,U. Şahin
2008 · DOI: 10.4049/jimmunol.180.1.309
Journal of Immunology · 171 Citations
TLDR
It is reported that combining an N-terminal leader peptide with an MHC class I trafficking signal (MITD) attached to the C terminus of the Ag strongly improves the presentation of MHCclass I and class II epitopes in human and murine dendritic cells (DCs).