Improving Transdermal Donepezil Delivery: A Comprehensive Design Expert Screening Method for a Dependable supply in Alzheimer’s Disease Management

Introduction: The benefit of systemic Donepezil absorption by transdermal patches is that they avoid hepatic first-pass metabolism. They make it possible for drugs to be gradually and carefully released into the bloodstream through unbroken skin. Aim: The purpose of this study was to use a central composite design to manufacture and describe transdermal patches containing Donepezil (DPZ). Materials and Methods: Using a solvent-casting technique, PVP K30, HPMC K15, and modified chitosan were used to make the patches. The formulas were created using Design Expert software, which also produced a central composite design, which was used to examine how independent variables affected the result. The FTIR technique was applied to investigate DPZ-excipient interactions. Results: The patches demonstrated good appeal and uniformity in thickness and content. The folding ability of the patches was more than 150, and the DPZ permeated from the patches was extended beyond 24 h in a controlled manner . Conclusion: The study concludes that using HPMC K15 (125 mg) and PVP K30 (40 mg) with modified chitosan (65.9 mg) effectively facilitates the permeation for the extended period and flexibility of DPZ transdermal