Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans
Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans
Carsten T. Charlesworth,Priyanka S. Deshpande,7 Authors,M. Porteus
2018 · DOI: 10.1101/243345
bioRxiv · 856 Citations
TLDR
There are pre-existing humoral and cell-mediated adaptive immune responses to Cas9 in humans, a factor which must be taken into account as the CRISPR-Cas9 system moves forward into clinical trials.