Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
B. Keele,E. Giorgi,34 Authors,G. Shaw
2008 · DOI: 10.1073/pnas.0802203105
Proceedings of the National Academy of Sciences of the United States of America · 1,994 Citations
TLDR
A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.