Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers

It is demonstrated that in differentiating mouse embryonic stem cells, MLL3/4-dependent deposition of H3K4me1 at enhancers correlates with increased levels of chromatin interactions, whereas loss of this histone modification leads to reduced levels of Chromatin interactions and defects in gene activation during differentiation.