High-throughput bioprinting to produce micropatterened neuroepithelial tissues and model TSC2-deficient brain malformations.
High-throughput bioprinting to produce micropatterened neuroepithelial tissues and model TSC2-deficient brain malformations.
Negin Imani Farahani,Kenneth Kin Lam Wong,4 Authors,Lisa M Julian
2025 · DOI: 10.1016/j.crmeth.2025.101177
Cell Reports Methods · 0 Citations
TLDR
It is demonstrated that these scaffolded NETs (scNETs) exhibit key architectural and biological features of the human brain during normal and abnormal development-notably, hyperproliferation and structural malformations induced by TSC2 deficiency-and provide a robust drug screening tool.