HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
S. Hung,W. Chung,16 Authors,Yuan-Tsong Chen
2005 · DOI: 10.1073/PNAS.0409500102
Proceedings of the National Academy of Sciences of the United States of America · 1,126 Citations
TLDR
The results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese, and in particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.