Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
Christiane Iserman,Christine A. Roden,14 Authors,A. Gladfelter
2020 · DOI: 10.1016/j.molcel.2020.11.041
Molecules and Cells · 289 Citations
TLDR
Condensation of N-protein is RNA sequence and structure specific, sensitive to human body temperature, and manipulatable with small molecules, and presents a screenable process for identifying antiviral compounds effective against SARS-CoV-2.