Genome Regulation by Polycomb and Trithorax: 70 Years and Counting.
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting.
B. Schuettengruber,H. Bourbon,L. D. Croce,Giacomo Cavalli
2017 · DOI: 10.1016/j.cell.2017.08.002
Cell · 883 Citations
TLDR
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states.