Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
S. Fisher,M. Tremelling,33 Authors,J. Satsangi
2008 · DOI: 10.1038/ng.145
Nature Genetics · 469 Citations
TLDR
Results of a nonsynonymous SNP scan for ulcerative colitis and a previously unknown susceptibility locus at ECM1 are reported, providing the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.