Gene expression regulation mediated through reversible m6A RNA methylation
Gene expression regulation mediated through reversible m6A RNA methylation
Ye Fu,D. Dominissini,G. Rechavi,Chuan He
2014 · DOI: 10.1038/nrg3724
Nature reviews genetics · 1,646 Citations
TLDR
This Review focuses on reversible methylation through the most prevalent mammalian mRNA internal modification, N6-methyladenosine (m6A), and indicates dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins.