Gene expression perturbation in vitro--a growing case for three-dimensional (3D) culture systems.
Gene expression perturbation in vitro--a growing case for three-dimensional (3D) culture systems.
Anna Birgersdotter,R. Sandberg,I. Ernberg
2005 · DOI: 10.1016/J.SEMCANCER.2005.06.009
Seminars in Cancer Biology · 599 Citations
TLDR
How cell lines adapt to in vitro environments, to what degree they express markers of their tissues of origins and how cells grown in three-dimensional (3D) cultures may have more physiological interactions with neighbouring cells and extracellular matrix are reviewed.