Gallic acid inhibits migration and invasion of SCC-4 human oral cancer cells through actions of NF-κB, Ras and matrix metalloproteinase-2 and -9.
Gallic acid inhibits migration and invasion of SCC-4 human oral cancer cells through actions of NF-κB, Ras and matrix metalloproteinase-2 and -9.
Chao-Lin Kuo,Kuang-Chi Lai,3 Authors,Jing-Gung Chung
2014 · DOI: 10.3892/or.2014.3209
Oncology Report · 59 Citations
TLDR
Gallic acid inhibits migration and invasion of SCC-4 cells by inhibiting NF-κB expression causing suppression of MMP-2 and MMP 9 activity and may have potential as a therapeutic agent for the treatment of oral cancer.