Gab1, SHP2, and Protein Kinase A Are Crucial for the Activation of the Endothelial NO Synthase by Fluid Shear Stress
Gab1, SHP2, and Protein Kinase A Are Crucial for the Activation of the Endothelial NO Synthase by Fluid Shear Stress
M. Dixit,A. Loot,6 Authors,I. Fleming
2005 · DOI: 10.1161/01.RES.0000195611.59811.ab
Circulation Research · 87 Citations
TLDR
The role of the scaffolding protein Gab1 and the tyrosine phosphatase SHP2 in this signal transduction cascade in cultured and native endothelial cells is investigated to regulate the phosphorylation and activity of eNOS by a PKA-dependent but Akt-independent mechanism.