Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
T. Inagaki,Mihwa Choi,11 Authors,S. Kliewer
2005 · DOI: 10.1016/J.CMET.2005.09.001
Cell Metabolism · 1,795 Citations
TLDR
It is demonstrated that fibroblast growth factor 15 signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the first and rate-limiting step in the classical bile acid synthetic pathway.