Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2
Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2
A. Pilon,M. Arcasoy,5 Authors,D. Bodine
2008 · DOI: 10.1128/MCB.01087-08
Molecular and Cellular Biology · 109 Citations
TLDR
It is demonstrated that early progenitor cells fail to undergo terminal erythroid differentiation in Eklf−/− embryos, and a model in which EKLF-dependent activation and modification of the E2f2 locus is required for cell cycle progression preceding terminal eriesdroid differentiation is proposed.