Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
S. Abdalla,H. Lother,2 Authors,U. Quitterer
2004 · DOI: 10.1016/J.CELL.2004.10.006
Cell · 208 Citations
TLDR
Elevated levels of crosslinked AT1 receptor dimers on monocytes could sustain the process of atherogenesis, because inhibition of angiotensin II generation or of intracellular factor XIIIA activity suppressed the appearance of cross linked AT1 receptors and symptoms of atherosclerosis in ApoE-deficient mice.