Extracellular proton modulates GABAergic synaptic transmission in rat hippocampal CA3 neurons.
Extracellular proton modulates GABAergic synaptic transmission in rat hippocampal CA3 neurons.
Chunyi Zhou,C. Xiao,Chunyu Deng,Jiang Hong Ye
2007 · DOI: 10.1016/J.BRAINRES.2007.01.121
Brain Research · 12 Citations
TLDR
Extracellular proton modifies GABAergic synaptic transmission both presynaptically and postsynaptically, and this could be independent of ASICs and voltage-gated calcium channels, which may constitute a new mechanism underlying acidification-induced neurotoxicity.