Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation.
Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation.
S. Klaus,B. Rudolph,C. Dohrmann,R. Wehr
2005 · DOI: 10.1152/PHYSIOLGENOMICS.00299.2004
Physiological Genomics · 81 Citations
TLDR
Increased EE caused by skeletal muscle uncoupling is clearly due to a decreased muscle energy efficiency during activity combined with increased glucose oxidation and a compromised thermoregulation associated with increased overall heat loss at thermoneutrality.