Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death.
Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death.
D. P. Huynh,Hai-Tao Yang,2 Authors,S. Pulst
2003 · DOI: 10.1093/HMG/DDG175
Human Molecular Genetics · 143 Citations
TLDR
A link between cell death mediated by mutant ataxin-2 and the stability of the Golgi complex is suggested, suggesting the formation of intranuclear aggregates is not necessary for in vitro cell death caused by expression of full-length mutant atxin- 2.