Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease
Jiaolong Yang,Shilin Luo,7 Authors,Zhentao Zhang
2020 · DOI: 10.1016/j.nbd.2020.105218
Neurobiology of Disease · 107 Citations
TLDR
It is demonstrated that exosome-mediated ASO4 delivery may be an effective treatment option for PD by developing a safe and highly effective ASO delivery method by using exosomes.