Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study
Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study
R. Riley,Kym I. E. Snell,5 Authors,Gary S. Collins
TLDR
Riley and colleagues describe how to calculate the sample size required for external validation studies, and propose to avoid rules of thumb by tailoring calculations to the model and setting at hand.
Abstract
An external validation study evaluates the performance of a prediction model in new data, but many of these studies are too small to provide reliable answers. In the third article of their series on model evaluation, Riley and colleagues describe how to calculate the sample size required for external validation studies, and propose to avoid rules of thumb by tailoring calculations to the model and setting at hand.