Evaluation of Combined Treatment With Atorvastatin and SREBP2 Inhibitors Against Colorectal Cancer Cells Under Two-dimensional and Three-dimensional Culture Models
Evaluation of Combined Treatment With Atorvastatin and SREBP2 Inhibitors Against Colorectal Cancer Cells Under Two-dimensional and Three-dimensional Culture Models
Kyota Ishii,Yuno Tauchi,Tomohiro Yano
2026 · DOI: 10.21873/anticanres.18126
Anticancer Research · 0 Citations
TLDR
3D cultured cells may possess an SREBP2-independent mechanism of statin resistance that differs from that of 2D cultured cells, and the efficacy of a combined statin and SREBP2 inhibitors strategy differs substantially between 2D and 3D cultured CRC cells.