Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
D. Zheng,Gayatree Mohapatra,27 Authors,E. Elinav
2023 · DOI: 10.1038/s41590-023-01450-z
Nature Immunology · 21 Citations
TLDR
It is shown that mouse Nlrp10 is expressed in distal colonic intestinal epithelial cells (IECs) and modulated by the intestinal microbiome and that this inflammasome is protective in dextran sodium sulfate-induced colitis in mice.