Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells.
Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells.
G. Song,N. Fiaschi-Taesch,A. Bisello
2009 · DOI: 10.1210/me.2009-0098
Molecular Endocrinology · 40 Citations
TLDR
PTHrP promotes down-regulation of the PTH1R in VSMC, thereby regulating cell proliferation in an auto/paracrine fashion and may have important implication during vascular remodeling, in particular in the development of neointima after arterial injury, where P THrP overexpression occurs.