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Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Sayaka Takayanagi,Takatoshi Tokunaga,3 Authors,Y. Shimohigashi

2006 · DOI: 10.1016/J.TOXLET.2006.08.012
385 Citations

TLDR

It is shown that BPA strongly binds to human estrogen-related receptor gamma (ERRgamma), an orphan receptor and one of 48 human nuclear receptors, which is expressed in a tissue-restricted manner and in the adult in the brain, lung and other tissues.