Elucidating the role of matrix stiffness in 3D cell migration and remodeling.
Elucidating the role of matrix stiffness in 3D cell migration and remodeling.
M. Ehrbar,A. Sala,6 Authors,M. Lutolf
2011 · DOI: 10.1016/j.bpj.2010.11.082
Biophysical Journal · 354 Citations
TLDR
This aECM model system is well suited to unveil the role of biophysical and biochemical determinants of physiologically relevant cell migration phenomena, with a similar stiffness dependence of matrix remodeling, albeit less sensitive to the matrix metalloprotease sensitivity.