Early Alzheimer’s disease pathology in human cortex involves transient cell states
Early Alzheimer’s disease pathology in human cortex involves transient cell states
Vahid Gazestani,Tushar Kamath,21 Authors,Evan Z. Macosko
2023 · DOI: 10.1016/j.cell.2023.08.005
Cell · 118 Citations
TLDR
A single-nucleus atlas from a rare cohort of cortical biopsies from living individuals with varying degrees of AD pathology provides an organizing framework for targeting circuit dysfunction, neuroinflammation, and amyloid production early in AD pathogenesis.