EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
J. Nieminuszczy,R. Broderick,10 Authors,W. Niedzwiedz
2019 · DOI: 10.1016/j.molcel.2019.05.026
Molecules and Cells · 27 Citations
TLDR
This work identifies a mechanism underpinned by EXD2’s nuclease activity, by which cells balance fork regression with fork restoration to maintain genome stability, and identifies a non-redundant role in replication fork protection.