Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.
Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.
Vivek Bhalla,R. Soundararajan,2 Authors,D. Pearce
2006 · DOI: 10.1152/AJPRENAL.00061.2006
103 Citations
TLDR
Interestingly, both SGK1 and GILZ appear to negatively regulate tonic inhibition of ENaC and thus use disinhibition to propagate the rapid effects of aldosterone to increase sodium reabsorption in tight epithelia.