Direct assessment of renal mitochondrial redox state using hyperpolarized 13C-acetoacetate
Direct assessment of renal mitochondrial redox state using hyperpolarized 13C-acetoacetate
C. von Morze,Michael A. Ohliger,6 Authors,Z. J. Wang
2018 · DOI: 10.1002/mrm.27054
Magnetic Resonance in Medicine · 30 Citations
TLDR
The purpose of this study was to investigate the hyperpolarized ketone body 13C‐acetoacetate (AcAc) and its conversion to13C‐β‐hydroxybutyrate (βOHB) in vivo, catalyzed by β‐Hydroxy butyrate dehydrogenase (BDH) as a novel direct marker of mitochondrial redox state.
Abstract
The purpose of this study was to investigate the hyperpolarized ketone body 13C‐acetoacetate (AcAc) and its conversion to 13C‐β‐hydroxybutyrate (βOHB) in vivo, catalyzed by β‐hydroxybutyrate dehydrogenase (BDH), as a novel direct marker of mitochondrial redox state.