Differential expression of steroid 5alpha-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer.
Differential expression of steroid 5alpha-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer.
K. Das,P. Lorena,6 Authors,M. Salto‐Tellez
2010 · DOI: 10.1677/ERC-10-0022
Endocrine-Related Cancer · 43 Citations
TLDR
It is suggested that SRD5A1 expression predominates in advanced PC, and that inhibition of SRD3A1 and SRD4A2 together was more effective in reducing cell numbers than inhibition ofSRD5a2 alone.