Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons.

It is found that inducing activity in layer 5 PNs resulted in endocannabinoid-mediated depolarization-induced suppression of excitation (DSE), whereas the majority of inhibitory inputs were cannabinoid insensitive, suggesting specificity of cannabinoid signaling across glutamatergic inputs.