Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.
H. Uhlig,Brent S. McKenzie,8 Authors,F. Powrie
2006 · DOI: 10.1016/J.IMMUNI.2006.05.017
Immunity · 238 Citations
TLDR
The experiments identified IL-23 as an effector cytokine within the innate intestinal immune system and suggests that it may make a more specific target for the treatment of IBD.