Deferoxamine preconditioning to restore impaired HIF‐1α‐mediated angiogenic mechanisms in adipose‐derived stem cells from STZ‐induced type 1 diabetic rats
Deferoxamine preconditioning to restore impaired HIF‐1α‐mediated angiogenic mechanisms in adipose‐derived stem cells from STZ‐induced type 1 diabetic rats
M. Mehrabani,Mohammad Najafi,5 Authors,Ali Sharifi
2015 · DOI: 10.1111/cpr.12209
Cell Proliferation · 67 Citations
TLDR
This study sought to explore effectiveness of pharmacological priming with deferoxamine (DFO) as a hypoxia mimetic agent, to restore the compromised angiogenic pathway, with the aid of ADSCs derived from streptozotocin‐induced type 1 diabetic rats (‘diabetic ADSCs’).