DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.
D. Crighton,S. Wilkinson,7 Authors,K. Ryan
2006 · DOI: 10.1016/J.CELL.2006.05.034
Cell · 1,409 Citations
TLDR
DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy, is described as an effector of p53-mediated death and its relationship to p53 function and damage-induced programmed cell death is highlighted.