DGAT1 Inhibition Enhances Olaparib-Induced Lipotoxic Apoptosis in Metastatic Castration-Resistant Prostate Cancer.
DGAT1 Inhibition Enhances Olaparib-Induced Lipotoxic Apoptosis in Metastatic Castration-Resistant Prostate Cancer.
Md Niaz Morshed,Philip S. Fitchev,5 Autori,Omar E Franco
2025 · DOI: 10.1096/fj.202501046R
The FASEB Journal · 0 citazioni
TLDR
This study proposes a novel therapeutic strategy to enhance Olaparib efficacy and potentially prevent resistance by targeting autophagy-induced LD biogenesis through DGAT1 inhibition, providing a foundation for clinical trials in patients with mCRPC.