DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
T. Geijtenbeek,D. Kwon,9 Authors,Y. Kooyk
2000 · DOI: 10.1016/S0092-8674(00)80694-7
Cell · 2,588 Citations
TLDR
It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.