Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.
Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.
Zizhen Gong,Jiefei Zhou,6 Authors,Jin Wu
2013 · DOI: 10.1002/mnfr.201500316
Molecular Nutrition & Food Research · 270 Citations
TLDR
This work finds that curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity and offers a mechanistic basis for the therapeutic potential ofCurcumin in septic shock and other NLRP2 inflammaome-driven diseases.