Crystal structures of human α‐defensins HNP4, HD5, and HD6

The high‐resolution X‐ray structures of three human defensins, 4 through 6, supplemented with studies of their antimicrobial and chemotactic properties are presented, finding the strongest cationic properties and unique distribution of charged residues on the molecular surface of HD5 may be associated with its highest bactericidal activity among human α‐defensins.