Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
M. Ferraroni,S. del Prete,2 Authors,C. Supuran
2015 · DOI: 10.1107/S1399004715018635
Acta Crystallographica Section D: Biological Crystallography · 99 Citations
TLDR
The cloning and kinetic characterization of the β-CA from Vibrio cholerae (VchCAβ) is reported, and it cannot be excluded that interference with their activity may be exploited therapeutically to obtain antibiotics with a different mechanism of action.