Cryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43
Cryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43
Mingkuan Sun,W. Bell,7 Authors,Liam Chen
2017 · DOI: 10.1007/s00401-017-1701-2
Acta Neuropathologica · 66 Citations
TLDR
The notion that the functional consequence of nuclear depletion of TDP-43 as determined by cryptic exon incorporation likely occurs as an early event of T DP-43 proteinopathy and may have greater contribution to the pathogenesis of AD than currently appreciated is supported.