Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
D. Bonen,Y. Ogura,9 Authors,G. Núñez
2003 · DOI: 10.1053/GAST.2003.50019
Gastroenterology · 441 Citations
TLDR
Functional studies revealed that the G908R, R702W, and L1007fsinsC variants in the presence and absence of P268S are defective in their ability to respond to bacterial LPS and PGN, whereas P 268S alone exhibited wild-type activity.