Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
C. Tsou,W. Peters,5 Authors,I. Charo
2007 · DOI: 10.1172/JCI29919
Journal of Clinical Investigation · 1,136 Citations
TLDR
It is reported that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2(-/-) mice, suggesting that CCR 2 is critical for monocyte egress.